karamd gut bio max review
January 13, 2022 11:31 am

Review of KaraMD GutBio Max: Worth It? A Dietitian Examines

Share this

By purchasing from some (not all) of our links mentioned in this post, we may receive a small commission.

karamd gutbio align rating

Fit Healthy Momma Rating: 9.5/10 ⭐

GutBio Max (previously GutBio Align) by KaraMD is a legit gut health probiotic, prebiotic and postbiotic supplement aimed to maintain healthy digestion and overall gut health comprised of natural plants and minerals, made in the USA in an FDA registered facility.

Have you ever had to take an antibiotic for an extended period and noticed your stomach felt kind of icky afterward? Or perhaps you noticed brain fog after eating poorly for a week while you were on vacation. Or maybe you noticed a decline in your mood while simultaneously noticing an increase in seasonal allergy symptoms.

These symptoms could be a sign of a gut imbalance. KaraMD GutBio Max claims to be one product that can help with some of these gut imbalance issues but are these claims true? Let’s take a look at the KaraMD GutBio Max supplement by a registered dietitian (that’s me!).

Why is Gut Health Important?

Often called our second brain, the gut or gastrointestinal tract has a huge impact on not just our body but also our mind. Have you ever noticed that you get “butterflies in your stomach” whenever you feel nervous? This is your brain sending a signal saying “you are nervous” to your stomach. The brain sends this signal by way of the vagus nerve. The vagus nerve is a direct line between your brain and your gut. Interestingly, the gut can also send signals to your brain almost as if your gut is a second brain. Since the mood neurotransmitters, dopamine, and norepinephrine, reside in the gut, the gut can send signals telling the brain “what mood you are in” so to speak.

gut health importance

This is why poor gut health can increase your risk of developing mood disorders like depression and anxiety. Poor gut health can also cause brain fog and increase your risk of dementia, Alzheimer’s disease, and other forms of cognitive decline.

The gut can also have a huge impact on your immune system. In fact, 70% of the immune system is located in the gut (1).

Gut imbalance has also been linked to an increased risk of heart disease, stroke, diabetes, certain cancers, autoimmune disease, and neurodegenerative diseases (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16).

Gut health may even play a role in weight loss/weight gain. In other words, a healthy gut microbiome may promote intentional weight loss. Inversely, a gut microbiome imbalance may hinder weight loss goals and may even promote unwanted weight gain (18).

Quick Summary of KaraMD GutBio Max Review


GutBio Max




Dr. Mahmud Kara


Product best for:

Improve digestion and overall gut health

Made in USA:



$34.95 for 1x purchase, or $31.46 if you buy 3, or $27.96 if you buy 4


Subscribe and save model

Subscription Option:


Avg. User Rating:

4.2/5 ⭐ (over 1,200 reviews on Walmart, Amazon and Official Website)

FHM Rating:

9.5/10 ⭐ (Excellent)

karamd gutbio align bottle and summary review

What is GutBio Max by KaraMD?

The KaraMD company was developed by Dr. Kara in 2018. KaraMD provides a variety of supplements that focus on gut health, heart health, and reducing chronic inflammation. While the GutBio Max supplement focuses on gut health, gut health can also indirectly impact heart-healthy and chronic inflammation. GutBio Max comes in capsule form and powder form. Let’s look at the pros and cons of the this gut health supplement.  

karamd gutbio align front and back labels


  • Lab tested for quality
  • Non-GMO
  • Gluten Free
  • Vegan
  • Made with natural plants and minerals
  • You can choose capsules or powder
  • Made in the USA in an FDA Registered Facility
  • Prebiotics, Probiotics and Postbiotics


  • Not Labeled as Third-Party Tested
  • Relatively pricey for some people (it's high quality)
karamd gutbio align pill size

Ingredients Analysis

This supplement contains about 40 calories, 3 grams of protein, and 1 gram of sugar. It also contains about 3 grams of beneficial fiber. GutBio Max also states that it contains 10 billion colony-forming units of probiotics. You want to see 1 billion CFUs or more in a probiotic product. GutBio Max adequately exceeds this recommendation. 

ingredients in gutbio align by karamd

The benefits of the ingredients listed in KaraMD GutBio Max have been well established by extensive research. Let's take a closer look at that below.


Overwhelming evidence suggests that probiotics may help reduce the risk or help with symptoms of:

  • Mood disorders like depression, anxiety, and stress
  • Certain cancers
  • Brain fog, cognitive decline, Alzheimer’s disease, and dementia
  • Chronic, Autoimmune, and neurodegenerative diseases
  • Acne
  • Cold, Flu, and other viruses
Probiotics and Mood disorders

Animal and human studies suggest that probiotics may help with mood disorders. In one study, mice were divided into two groups. One group of mice received probiotics, and one group of mice received a placebo. The mice that consumed probiotics were more calm and relaxed compared to the placebo group (2, 3).

Human trials, including randomized, double-blinded, placebo-controlled trials, observed a significant reduction in depression, anxiety, and stress symptoms when participants were given probiotics (2, 4, 5, 7).

Probiotics and Cancers Prevention

Due to its anti-inflammatory properties, probiotics may help reduce the risk of cancer. Animal trials, as well as research on human cancer cells, found anti-cancer properties in probiotics. Some studies have even shown anti-cancer effects in patients with cancer (8).

Probiotics and Cognitive Decline

Studies have shown that probiotics may help with memory and focus. Several rat studies have shown an increase in cognitive function and memory after the rats were given probiotics.

In one study, lead-exposed rats were given probiotics. Interestingly, after the rats were given probiotics the rat’s memory was repaired (9).

Probiotics may help improve cognitive function and memory in people with Alzheimer’s as well, according to a double-blinded, placebo-controlled study (10).

Probiotics and Chronic, Autoimmune, and Neurodegenerative Diseases

Chronic disease includes diseases like heart disease, stroke, and diabetes. Multiple Sclerosis, Rheumatoid Arthritis, Ulcerative Colitis, Irritable Bowel Disease, Lupus, and Crohn’s disease are all types of autoimmune diseases. Neurodegenerative diseases include Alzheimer’s disease, Parkinson’s disease, and ALS. What do all these diseases have in common? Probiotics may reduce the risk or help with the symptoms of all of them.

In fact, forty years of research, including animal and human trials, have suggested that probiotics may reduce the risk or help with symptoms of these diseases in varying degrees (11, 12, 13, 14, 15).

Probiotics and Acne

According to a recent review, probiotics may help prevent and improve acne. Probiotics may help with acne by not only stabilizing the gut microbiome but by also stabilizing the skin microbiome (19).

Probiotics and the Immune System

According to a systematic review, probiotic consumption may reduce the frequency and severity of colds, flu, and other viruses.  In other words, people who consume probiotics may be slightly less likely to come down with a contagious illness (16).


Prebiotics are important for gut health because they feed probiotics, helping the probiotics thrive in the gut. Prebiotics are found in many fiber-rich foods like chickpeas, bananas, oats, and apples. Prebiotic fiber also provides other benefits as well. Fiber promotes satiety; therefore, fiber can aid in weight loss. KaraMD 

GutBio Max lists 3 grams of fiber on the nutrition label. The prebiotic fiber in this supplement comes from agave inulin, flaxseed, acacia gum, and banana powder.


Postbiotics, as the name indicates, are the byproducts or waste products leftover when  probiotics eat prebiotics. This process can happen inside and outside the body. Some of the byproducts often produced are short-chain fatty acids, and functional proteins and peptides (smaller amino acid chains). These byproducts provide similar benefits as prebiotics and probiotics (20).

Postbiotics have a few advantages over probiotics, however. Postbiotics are more stable and have a longer shelf-life, meaning they will last longer in products. They are also less sensitive to cold temperatures (21).

Are there Any Side Effects from Taking GutBio Max?

taking gut bio align with water

Probiotics, prebiotics, and postbiotics are generally regarded as safe and often recommended by doctors and dietitians. Of course, you should always talk with your doctor about possible supplements you are using. Your doctor will be able to tell you about any interactions your supplement could have with your medications or medical conditions. 

taking karamd gutbio align side effects

Some reviewers also reported more gas when they first started using GutBio Max. This is often quite normal when you make gut healthy changes to your diet and increase your fiber intake. After your body adapts to the changes the gas usually significantly decreases.

Cost and Where to Buy

Although subject to change, as of writing this post, KaraMD Gutbio Max is $34.95 per bottle. Each bottle contains 40 capsules. You can buy this supplement as well as other KaraMD products on Karamd.com. I also found KaraMD products, including the GutBio Max, available on Walmart online and Amazon. 

gutbio MAX purchase on karamd website

If a product is available at the brand's official website, we always recommend to purchase there to avoid 3rd party mishaps on sites like Amazon or Walmart... sometimes, you just never know what you're going to get.

Visit Official Website | Visit Amazon | Visit Walmart

Ratings and Reviews: What are the Customers Saying After Using it?

GutBio Max by KaraMD has a 4.2/5 star rating on both Walmart and Amazon, as well as their official website. All together, there are over 1,200 reviews, which is a significant sample size to base an opinion off of.

Many of the reviewers are very happy with their purchase and can really tell the difference after taking the supplement for the recommended amount of time.

One review stated how she was "very skeptical" at first, especially after trying many other gut health supplements, but GutBio Max actually works!

Let's take a look at some other reviews so you can see for yourself.

customer review karamd gut align
user review karamd gut align

Worth It? A Dietitian’s Recommendation

Since gut health can have an impact on almost every organ and process in our body, improving or maintaining gut health is vital. KaraMD GutBio Max is one product that may help support gut health and healing. Based on this data, I would say KaraMD GutBio Max is worth it, and I would recommend it as a helpful option for some people.

worth it karamd gutmax

Gut Health Tips from the RD

  • Eat probiotic-rich foods 4-5 times a week. Probiotic-rich foods include yogurt, kimchi, kefir, kombucha, miso, and fermented vegetables like sauerkraut and pickles. 
  • Eat fiber-rich foods at every meal. To increase your fiber intake, eat whole grains 2-3 times a day, vegetables at every meal, nuts 5 times a week, and fruit every day. 
  • You can also consider supplementing your healthy diet with probiotic, prebiotic, and postbiotic supplements or foods fortified with probiotics.

Verified Review

karamd gut max verified review

About the author 

Lacy Ngo

Lacy Ngo, MS, RDN is a registered dietitian with a Master’s in Human Nutrition. Ngo is also the author of several books including, “The Nourishing Meal Builder.” Ngo has been featured and quoted in publications like Parade Magazine, The Healthy, Fitbit.com, Eat This, Not That!, VeryWell Fit, Byrdie, Authority Magazine, Fitbit, and Fitwirr. Lacy is passionate about fitness and came in 5th place in her group in the Ms. Health & Fitness Competition.

You may also like

Leave a Reply

{"email":"Email address invalid","url":"Website address invalid","required":"Required field missing"}

Join the Fit Home, Healthy Life Facebook Group