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Essential fatty acids are, well, essential for the health and longevity of our bodies. However, our bodies cannot make them on their own, so we must get them from the foods we eat or the supplements we take. In fact, many people supplement their diets with Omega-3s as this has long been one of the best fatty acid supplements available.

However, there’s a new essential fatty acid in town, C15:0, that’s changing the way we see, understand, and supplement with fatty acids. Fatty15 is the first and only science-backed, award-winning C15:0 supplement on the market.

So this begs the question; which is better: Fatty15 or Omega-3s? Should you take both? 

Both C15:0 and Omega-3s provide clinically-proven cellular and immune health benefits that support your long-term health and wellness, there’s no doubt about that. But, let’s break it down and compare the two head-to-head in an in-depth analysis.

In this article, we’re dissecting the research to answer all of your questions on the differences and similarities between Fatty15 and Omega-3s so that you can make an informed decision as to which fatty acid supplement(s) are the best fit for your healthy lifestyle.

What Are Essential Fatty Acids and Why Do We Need Them?

Essential fatty acids (EFA) are nutrients that our bodies need but do not make on their own. Therefore, our primary sources of essential fatty acids come from the foods we eat and dietary supplements. 

Contrary to what we’ve been told for the majority of our lives, all fats, including saturated fatty acids, play important roles in our bodies. Essential fatty acids are the most important for us to pay attention to because they must come from the food we eat or we must supplement our diets with a reliable nutritional dietary supplement.

Up until recently, the EFAs that we focused on were linoleic acid (omega-6) and alpha-linolenic acid (omega-3), both of which are necessary for our survival. Multiple studies have shown that increasing our intake of certain essential fatty acids can improve our health across varying markers and systems. Below are just a few of the proven benefits of EFAs:

  • Formation of healthy cell membranes.
  • Development and functioning of the brain and nervous system.
  • Improved thyroid and adrenal activity.
  • Balanced hormone production.
  • Regulation of blood pressure, liver function, immune and inflammatory responses.
  • Improved mental and physical performance.
  • Body composition changes.

Research has shown that both C15:0 and omega-3s are essential because they both support immune and metabolic health, however, they are not one and the same. Let’s start to break down and compare the two.

Quick Summary of Fatty15 vs Omega 3: Comparison Table

comparison omega 3s versus fatty15




Type of Fatty Acid:

Polyunsaturated essential fatty acid

Saturated essential fatty acid†

Ingredients Used:

Fish or algae oils

FA15™ powder in fatty15

Fish After taste and smell:

(responsible for that famous smell)

(no taste or smell at all)

Dosage & Effects:

(2k-3k mg per day)

(100 mg per day)

Where to buy:

Recommended omega-3 supplement: 1st Phorm Full Mega (see our guide on other top omega-3 supplements for women)

fatty15.com (use code FHMNOV for 30% off the 90-day subscription package)

What Is Fatty15?

holding fatty15 supplement

Fatty15 is a once-daily oral supplement that can help counter natural age-related breakdown. This supplement has been shown to strengthen cell membranes, keep mitochondria working, and naturally activate receptors throughout the body and brain that regulate functions like immunity, metabolism, mood, appetite, and sleep.

Fatty15 contains just one single ingredient; pure pentadecanoic acid, or C15:0. This is a first-of-its-kind supplement that was researched and developed by Dr. Eric Venn-Watson and Stephanie Venn-Watson, a Veterinary Epidemiologist and Public Health Scientist who spent years working with dolphins to understand how they age and how to improve their aging.

After some groundbreaking research, Stephanie and the team were able to take the results they discovered in dolphins around the supplementation of C15:0 and correlate that to humans. Fatty15 is a discovery 90 years in the making and it’s not only helping to save the dolphins but humankind, too.

Get 30% off the 90-day subscription plan by using code: FHMNOV

What Are Omega 3s?

holding omega 3 supplement

Omega-3 fatty acids are found in foods like fish and flaxseed as well as in dietary supplements like fish oil. There are three main omega-3s: alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

Omega-3s are important components of the membranes that surround each cell in your body, therefore, they are considered essential fatty acids. The food richest in omega-3s include fatty fish like salmon, mackerel, tuna, sardines, nuts and seeds, and plant oils. In supplement form, omega-3s are from oils including fish oil, krill oil, cod liver oil, and algal oil.

Fatty15 vs Omega 3s: A Head-to-Head Comparison

fatty 15 and omega 3 compare

Science supports the fact that both C15:0 and omega-3 fatty acids are essential fatty acids that can help regulate your immune system as well as your metabolism, but they are not the same. Let’s compare these two head-to-head based on the following criteria:

Type of Fat

Omega-3s are a polyunsaturated essential fatty acid and Fatty15 (C15:0) is a saturated essential fatty acid. When a fatty acid is unsaturated, its chemical structure has double bonds. Double bonds serve as bending points that make them more fragile, and polyunsaturated fats actually have multiple double bonds, making them even more fragile. This is why omega-3s are oils at room temperature.

Fatty15, on the other hand, is saturated fat, as indicated by the absence of double bonds. Naturally, these saturated fatty acids are stronger and more resilient thanks to their lack of bending points and pliability. This allows them to help your cells become stronger and more stable, thereby making them less likely to show signs of breakdown with age.

Oxidation Risk

Omega-3s are oils that are readily oxidized by oxygen. In simple terms, when omega-3s are exposed to oxygen, they start going bad. This process is known as lipid peroxidation or going rancid. Unfortunately, studies have shown that as many as half of omega-3 supplements available on the shelf have gone rancid, but they can also go bad in your cells.

Fatty15 does not pose an oxidation risk. Omega-3s can cause cell damage or death, whereas C15:0 has only been shown to strengthen and protect cells. Over time, the oxidation of omega-3s can result in age-related breakdown due to their fragility and oxidative stress.


Fatty15 contains only one ingredient; pure FA15. This pure-powder, vegan-friendly, patented, and award-winning ingredient is the only thing you’ll find inside Fatty15.

In contrast, omega-3s are typically made with multiple ingredients, mostly machine-processed fish. Plus, up to 50% of the omega-3s that make their way to the shelf have already been oxidized, which means that they can trigger cell breakdown as opposed to cell protection, which is what we actually are seeking.


Anyone who has ever taken an omega-3 supplement already knows that they taste and smell like fish. I mean, they are made from fish oil, so it makes sense! Even the omega-3 brands that claim no fishy burps and fishy aftertaste are usually nothing more than a sales ploy because it’s incredibly hard to mask the fishy essence inherent in fish oil.

Fatty15 contains no fish oil, therefore, it’s 0% fishy. FA15 is a pure, scentless, tasteless powder.

Required Dosage

The recommended dosage for omega-3 supplements is quite large, usually between 2,000-3,000 mg per day. Fatty15’s dose is much smaller at just 100mg per day.


A typical Omega-3 capsule is large and you’re usually required to swallow 2-3 of them at once to get the full recommended dose. In comparison, Fatty15’s capsule is much smaller and easier to take. Those who struggle with taking Omega-3s because of the size of the capsules will be elated with the size and ease of Fatty15’s capsule.

omega 3 capsule
fatty 15 capsule

Side Effects

There has only been one side effect reported thus far with Fatty15 and that is a reduction in appetite/snacking, a side effect that most of us would truly enjoy and benefit from. Omega-3s, on the other hand, have a handful of side effects that are a tad less pleasant. Side effects of omega-3s include; fishy breath, fishy burps, upset stomach, nausea, and loose stools.

Clinically Proven Outcomes

clinical outcomes fatty15 and omega3

This recent peer-reviewed scientific study comparing Fatty15 to omega-3 found the following:

  1. Fatty15 has 36 clinically relevant cellular benefits whereas Omega-3 has only 10.
  2. Fatty15 repairs 83% of the 12 cell types tests. Omega-3 can only repair 33%.
  3. Fatty15 is safe for all cells at all concentrations. Omega-3 is toxic to 4 of the 12 cell systems tested when taken at its highest dose.

In summary, Fatty15 is superior at restoring cellular health when it’s compared to omega-3.

Table Depiction of Specific Cell Related Benefits (Omega-3 vs Fatty15)

Benefits to health systems

Omega-3 (EPA)

Fatty15 (C15:0)

Immune and gut:

Heart, joint, and metabolic:

Immune, joint, skin, gut, red blood cell:

Immune, lung:

Heart, Immune:


Joint, tissue:







Naturally, when new research and findings are discovered that shake up the way we approach our health, you’re going to have some questions. This is especially pertinent if you’re someone who has taken an omega-3 supplement religiously. Let’s take a look at some of the frequently asked questions next.

What If I already Take an Omega-3 Fatty Acid Supplement?

If you’re already taking an omega-3 supplement, great! You can still continue to take your omega-3s and also add in Fatty15, or you can discontinue taking your omega-3 and replace it with Fatty15.

Taking Fatty15 provides you with additional benefits. Most importantly, Fatty15 has been shown to increase the resiliency of our aging cells whereas omega-3 fatty acids have been shown to result in increased flexibility in our cells, leaving them more susceptible to cellular breakdown as we age.

Can I Take Them Together?

Yes, you sure can. Both Fatty15 and omega-3s are considered to be essential fatty acids, both of which can be taken simultaneously as part of your daily essential fatty acid routine. 

Absolutely. Both C15:0 (the only ingredient in fatty15) and omega-3s are considered essential fatty acids, which can be taken together as part of your daily essential fatty acid supplement routine.

See our best women's omega-3 supplements.

Can Fatty15 Replace Omega3s?

Yes, but it’s important to keep in mind that these two fatty acids are not identical. Specifically, C15:0 is a (healthy) saturated fatty acids and omega-3s are polyunsaturated fatty acids. Both are essential for your health, so you should be aiming to get both. However, Fatty15 has been proven superior to omega-3s when it comes to cellular health, so if you’re taking Omega-3s for cellular-health-related benefits, Fatty15 is the more impactful choice. 

If I Can’t Take Omega-3s, Can I Take Fatty15?

For many, taking omega-3 fish oil supplements is difficult due to the large capsules and high daily doses. Not to mention the fishy burps and propensity for gastrointestinal issues. In contrast, Fatty15 is much easier to take thanks to its small dosage and capsule size as well as the fact that it’s completely taste and scent-free.

Final Thoughts: Which is Better…Fatty15 or Omega-3s?

better cellular health fatty15 or omega3

In the case of Fatty15 vs Omega3s, the data doesn’t lie - Fatty15 is better for your cellular health and omega-3. That said, omega-3 is still an essential fatty acid and it will always bring health benefits to the table. The biggest key to omega-3 supplementation is making sure that you’re getting a high-quality product that’s less likely to be oxidized/rancid before you ever get the chance to take it.

All in all, the research that’s been done directly comparing the two is very clear; Fatty15 is more beneficial and easier to take than omega-3 fatty acid supplements. Plus, the near-term benefits that Fatty15 users are reporting like reduced snacking and cravings, better sleep, and increased energy, are making Fatty15 an even more appealing option for those looking to optimize their cellular health to ease aging more gracefully.


New study reveals Fatty15 is 3x better than Omega-3!

Use code FHMNOV for 30% off the 90-day subscription package

About the Author
Tami Smith, CPT, Nutritionist

Tami Smith is a certified Nutritionist and an ACE certified fitness trainer, specializing in pre and post-natal fitness. She studied business and earned her bachelor's degree in Business Economics. Tami is a mom of two and women's health advocate. Her passion is to help people live a fit, healthy life through proper nutrition and exercise!

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